Drug Tolerance

JNJ-20788560 [9-(8-Azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic Acid Diethylamide], a Selective Delta Opioid Receptor Agonist, Is a Potent and Efficacious Antihyperalgesic Agent That Does Not Produce Respiratory Depression, Pharmacologic Tolerance, or Physical Dependence

Pharmacology / Mice / Animals / Male / Self-administration / Rats / Gastrointestinal motility / Wistar Rats / Seizures / Opioid Receptor / Pain Measurement / Substance-Related Disorders / Hyperalgesia / Hot Temperature / Drug Tolerance / Rats / Gastrointestinal motility / Wistar Rats / Seizures / Opioid Receptor / Pain Measurement / Substance-Related Disorders / Hyperalgesia / Hot Temperature / Drug Tolerance

Significant correlation between plasma and CSF anticholinergic activity in presurgical patients

Neuroscience / Psychology / Cognitive Science / Aging / Delirium / Humans / Close relationships / Female / Male / Acetylcholine / Synaptic Transmission / Aged / Middle Aged / Anesthetics / Cognitive impairment / Correlation Analysis / Radioligand Assay / Age Factors / Biological markers / Brain Chemistry / Neurosciences / Predictive value of tests / Drug Tolerance / Humans / Close relationships / Female / Male / Acetylcholine / Synaptic Transmission / Aged / Middle Aged / Anesthetics / Cognitive impairment / Correlation Analysis / Radioligand Assay / Age Factors / Biological markers / Brain Chemistry / Neurosciences / Predictive value of tests / Drug Tolerance

Antimicrobial Drug Resistance

Veterinary Medicine / Virulence / Therapeutic drug monitoring / Mutation / Animals / Drug Resistance / Bacteria / Microbial genetic and drug resistance / Anti-Bacterial Agents / Time Factors / Bacterial infections / Drug Tolerance / Drug Resistance / Bacteria / Microbial genetic and drug resistance / Anti-Bacterial Agents / Time Factors / Bacterial infections / Drug Tolerance

Transactivation activity of human papillomavirus type 16 E6*I on aldo-keto reductase genes enhances chemoresistance in cervical cancer cells

Gene expression / Biological Sciences / HUMAN PAPILLOMAVIRUS / Humans / General / Female / Host Pathogen Interactions / Antineoplastic Agents / Drug Tolerance / Gene expression profiling / Female / Host Pathogen Interactions / Antineoplastic Agents / Drug Tolerance / Gene expression profiling

JNJ-20788560 [9-(8-Azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic Acid Diethylamide], a Selective Delta Opioid Receptor Agonist, Is a Potent and Efficacious Antihyperalgesic Agent That Does Not Produce Respiratory Depression, Pharmacologic Tolerance, or Physical Dependence

Mice / Animals / Male / Self-administration / Rats / Gastrointestinal motility / Wistar Rats / Seizures / Opioid Receptor / Pain Measurement / Substance-Related Disorders / Hyperalgesia / Hot Temperature / Drug Tolerance / Gastrointestinal motility / Wistar Rats / Seizures / Opioid Receptor / Pain Measurement / Substance-Related Disorders / Hyperalgesia / Hot Temperature / Drug Tolerance

DNA strand breakage, cytotoxicity and mutagenicity of hydrogen peroxide treatment at 4 degrees C and 37 degrees C in L5178Y sublines

DNA damage / DNA repair / Mutagenesis / Mutation / Mice / Animals / Drug Resistance / Temperature / Catalase / Hydrogen Peroxide / Cell Survival / Drug Tolerance / Animals / Drug Resistance / Temperature / Catalase / Hydrogen Peroxide / Cell Survival / Drug Tolerance

DNA strand breakage, cytotoxicity and mutagenicity of hydrogen peroxide treatment at 4 degrees C and 37 degrees C in L5178Y sublines

DNA damage / DNA repair / Mutagenesis / Mutation / Mice / Animals / Drug Resistance / Temperature / Catalase / Hydrogen Peroxide / Cell Survival / Drug Tolerance / Animals / Drug Resistance / Temperature / Catalase / Hydrogen Peroxide / Cell Survival / Drug Tolerance

JNJ-20788560 [9-(8-Azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic Acid Diethylamide], a Selective Delta Opioid Receptor Agonist, Is a Potent and Efficacious Antihyperalgesic Agent That Does Not Produce Respiratory Depression, Pharmacologic Tolerance, or Physical Dependence

Mice / Animals / Male / Self-administration / Rats / Gastrointestinal motility / Wistar Rats / Seizures / Opioid Receptor / Pain Measurement / Substance-Related Disorders / Hyperalgesia / Hot Temperature / Drug Tolerance / Alfentanil / Gastrointestinal motility / Wistar Rats / Seizures / Opioid Receptor / Pain Measurement / Substance-Related Disorders / Hyperalgesia / Hot Temperature / Drug Tolerance / Alfentanil

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